Gut health and probiotics

Research is investigating the role of probiotics in modulating the gut microbiome and their influence on gut health.

Gut health and probiotics

A recent review of probiotic supplementation in healthy adults suggests there is little evidence of an effect in healthy people.

However, in people with existing health conditions, there is research supporting a modest ability for specific probiotic strains to alleviate some disease symptoms such as gastrointestinal problems. The key is that many of the benefits appear to be strain-specific, so it is necessary to do a bit of research beforehand to make sure you get the right strains.

Curious to see if your probiotics are having an effect? Learn more with Microba Insight™

Explore further research articles listed below to learn more about these insights and uncover further links between the gut microbiome and probiotics.

Science blogs and digests

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Dual studies reveal probiotics offer no help to children with stomach virus

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Probiotics are only beneficial when your gut barrier is healthy, study finds

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Health Check: should healthy people take probiotic supplements?

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Probiotics for bipolar disorder mania

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Probiotics can protect the skeletons of older women

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Human gut study questions probiotic health benefits

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Probiotic found in yogurt can reverse depression symptoms

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Do probiotics have a beneficial effect on healthy adults?

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Impact on gut microbiota of fermented milk product containing probiotics revealed by new technology

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Daily doses of a new probiotic reduces 'bad' and total cholesterol


Bagga, D., et al.
Probiotics drive gut microbiome triggering emotional brain signatures.
Gut Microbes 9(6): 486-496. (2018). Doi: 10.1080/19490976.2018.1460015

Ciorba, M. A.
A gastroenterologist’s guide to probiotics.
Clinical gastroenterology and hepatology 10(9): 960-968. (2012). Doi: 10.1016/j.cgh.2012.03.024

Dickerson, F., et al.
Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: a randomized controlled trial.
Bipolar Disorders 20(7): 614-621. (2018). Doi: 10.1111/bdi.12652

Freedman, S.B., et al.
Multicenter trial of a combination probiotic for children with gastroenteritis.
The New England Journal of Medicine 379: 2015-2026. (2018). Doi: 10.1056/NEJMoa1802597

Hill, D., Ross, R. P., Arendt, E. & Stanton, C..
Chapter 4 - Microbiology of yogurt and bio-yogurts containing probiotics and prebiotics.
In Shah, N. (Ed.), Yogurt in Health and Disease Prevention (pp. 69-85). London, UK: Academic Press. (2017). Doi: 10.1016/B978-0-12-805134-4.00004-3

Nilsson, A.G., et al.
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial.
Journal of Internal Medicine 284(3): 307-317. (2018). Doi: 10.1111/joim.12805

Quin, C., et al.
Probiotic supplementation and associated infant gut microbiome and health: a cautionary retrospective clinical comparison.
Scientific Reports 8, 8283 (2018). Doi: 10.1038/s41598-018-26423-3

Sanders, M. E.
Probiotics and microbiota composition.
BMC Med. 14, 82 (2016). Doi: 10.1186/s12916-016-0629-z

Sanders, M. E., Benson, A., Lebeer, S., Merenstein, D. J. & Klaenhammer, T. R.
Shared mechanisms among probiotic taxa: implications for general probiotic claims.
Curr. Opin. Biotechnol. 49: 207-216. (2018). Doi: 10.1016/j.copbio.2017.09.007

Schnadower, D., et al.
Lactobacillus rhamnosus GG versus placebo for acute gastroenteritis in children.
The New England Journal of Medicine 379: 2002-2014. (2018). Doi: 10.1056/NEJMoa1802598

Suez, J., et al.
Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT.
Cell 174(6): 1406-1423. (2018). Doi: 10.1016/j.cell.2018.08.047

Tu M-Y, Chen H-L, Tung Y-T, Kao C-C, Hu F-C, Chen C-M.
Short-term effects of kefir-fermented milk consumption on bone mineral density and bone metabolism in a randomized clinical trial of osteoporotic patients.
PLoS ONE 10(12), e0144231 (2015). Doi: 10.1371/journal.pone.0144231

Veiga, P. et al.
Changes of the human gut microbiome induced by a fermented milk product.
Sci. Rep. 4, 6328 (2014). Doi: 10.1038/srep06328

Zmora, N., et al.
Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features.
Cell 174(6): 1388-1405. (2018). Doi: 10.1016/j.cell.2018.08.041

Khalesi, Saman, et al.
A review of probiotic supplementation in healthy adults: helpful or hype?.
European Journal of Clinical Nutrition 73: 24–37. (2019) . Doi: 10.1038/s41430-018-0135-9