Gut health and colon cancer

Research shows a number of correlations between the gut microbiome, gut bacteria, inflammation and colon cancer.

For example, studies have demonstrated accumulating evidence suggesting that chronic infection and inflammation may contribute to tumour initiation and progression. This could have significant implications in the prevention, diagnosis and therapy of colon cancer by targeting the gut microbiome.

Explore the research articles listed below to learn more about these insights and uncover further links between the gut microbiome and colon cancer.

Science Digests/Blogs

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Gut Microbes Combine to Cause Colon Cancer, Study Suggests

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Colon cancer is caused by bacteria and cell stress

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How gut microbes are joining the fight against cancer

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Study suggests colon cancer cells carry bacteria with them when they metastasize

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How your gut bacteria may protect you from cancer

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Gut bacteria mediate link between diet and colorectal cancer

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How our gut bacteria affect cancer risk and response to treatment

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New research on probiotics in the prevention and treatment of colon cancer

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New colon cancer culprit found in gut microbiome


Bhutia, Y. D., Ogura, J., Sivaprakasam, S. & Ganapathy, V.
Gut microbiome and colon cancer: role of bacterial metabolites and their molecular targets in the host.
Curr. Colorectal Cancer Rep. 13(2): 111-118. (2017). Doi: 10.1007/s11888-017-0362-9

Bullman, S. et al.
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer.
Science 358(6369): 1443-1448. (2017). Doi: 10.1126/science.aal5240

Chen G.Y.
The role of the gut microbiome in colorectal cancer.
Clin Colon Rectal Surg. 31(3): 192-198. (2018) . Doi: 10.1055/s-0037-1602239

Dai Z, Coker OO, Nakatsu G, et al.
Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.
Microbiome 6, 70 (2018). Doi: 10.1186/s40168-018-0451-2

Dejea, C. M. et al.
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
Science 359(6375): 592-597. (2018). Doi: 10.1126/science.aah3648

Pasquereau-Kotula E, Martins M, Aymeric L, and Dramsi S.
Significance of Streptococcus gallolyticus subsp. gallolyticus association with colorectal cancer.
Front Microbiol. 9, 614 (2018). Doi: 10.3389/fmicb.2018.00614

Sun, J. & Kato, I.
Gut microbiota, inflammation and colorectal cancer.
Genes & Diseases 3(2): 130-143. (2016). Doi: 10.1016/j.gendis.2016.03.004

Wu X, et al.
Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer.
Journal of Cancer 9(14): 2510-2517. (2018). Doi: 10.7150/jca.25324

Zackular, J. P., Rogers, M. A. M., Ruffin, M. T. & Schloss, P. D.
The human gut microbiome as a screening tool for colorectal cancer.
Cancer Prevention Research 7(11): 1112-1121. (2014). Doi: 10.1158/1940-6207.CAPR-14-0129

Zeller, G. et al.
Potential of fecal microbiota for early‐stage detection of colorectal cancer.
Mol. Syst. Biol. 10, 766 (2014). Doi: 10.15252/msb.20145645